LABORATORIO DE DESÓRDENES NEUROMOTORES Y NEUROCONDUCTUALES PROGRESIVOS
Director: Dr. Blas Couto
Integrantes: Dr. Gabriel Mizraji (Neurólogo), Lic. Federico Castaño (becario doctoral), Dra. María José Angel (fellow clínica), Florencia Alifano (CPA EEG), Tomás Falzone (colaborador UBA-IBioBA), Elena Avale (colaboradora externa INGEBI), Nicolas Vallenas (estudiante medicina NYU, EE.UU.), Laura Zaifrani (maestranda), Mateo Tomkowicz (estudiante medicina, Univ. Austral), Dra. Lucía Brolese (fellow clínica en movimientos anormales), Lic. Florencia Sobrero (estudiante de maestría), Lic. Eríca Guardiola (estudiante de maestría).
Líneas de investigación
Buscamos comprender con nuestros estudios la genética de los parkinsonismos, y las exposiciones medioambientales y los factores del estilo de vida que impactan en los síntomas de PSP y parkinsonismos. Además investigaremos las posibles interacciones genético-ambientales. Por otro lado, desarrollamos baterías de estudios cognitivos para el seguimiento de los cambios neuroconductuales de pacientes con PSP. En otra línea, profundizamos en el conocimiento de marcadores neurobiológicos (con EEG y potenciales evocados) de la impulsividad. Estudiamos la epidemiología, fenotipos clínicos, progresión y neurobiología molecular de pacientes con Parkinsonismo y demencia: Parálisis supranuclear progresiva, particularmente.
Principales publicaciones
Garcia-Cordero, I., Hadian, M., Vargas-Gonzalez, J.C., Monteiro, M., Gold, D., Khoja, A., Morales-Rivero, A., Couto, B., Tang-Wai, D., Fox, S., Kovacs, G.G., Lang, A.E. and Tartaglia, M.C. (2026), Cognitive, Motor and Oculomotor Contributions to the Trail Making Test in Progressive Supranuclear Palsy. Mov Disord Clin Pract. https://doi.org/10.1002/mdc3.70696
Martinez-Valbuena, I., Lee, S., Santamaria, E. et al. 4R-tau seeding activity reveals molecular subtypes in progressive supranuclear palsy. Nat Commun 17, 1006 (2026). https://doi.org/10.1038/s41467-025-67744-y
Maria Jose Angel Pinto; Indira García Cordero; Guido Dorman; Gabriel Mizraji; Chloe Anastassiadis; Oscar Gershanik y Blas Couto. Amyloid and Tau Co-pathology in Parkinson Disease and Atypical Parkinsonism. Current Neurology and Neuroscience Reports (2026) 26:21. https://doi.org/10.1007/s11910-026-01488-0
Jacy Bezerra Parmera, & Blas Couto. Biomarker-Based Corticobasal Syndrome Classification: The Added Value of Deep Phenotyping and Population Diversity. Movement disordes. 2026. ver articulo
Maria Jose Angel; Gabril F. Mizraji; Gonzalo Gomez-Arevalo; Garcia Silvia; Maria Eugenia Gonzalez-Toledo; Avale Elena; Paez-Paz Indiana; Falzone Tomas; Holubiec Mariana; C. Peralta Maria et al. Prospective longitudinal cohort of Argentinean patients with progressive supranuclear palsy and corticobasal syndrome: A platform for epidemiological and translational research. Clinical Parkinsonism & Related Disorders. 2025 DOI: 10.1016/j.prdoa.2025.100339
Blas Couto; Shelley L Forrest; Conor Fearon; Seojin Lee; Samantha Knott; Jun Li; Susan H Fox; Maria Carmela Tartaglia; Anthony E Lang; Gabor G Kovacs. Midbrain cytotoxic T cells as a distinct neuropathological feature of progressive supranuclear palsy. Brain. 2025-08-01 DOI: 10.1093/brain/awaf135
Alonso Morales‐Rivero; Indira Garcia‐Cordero; Abeer Khoja; Juan‐Camilo Vargas‐Gonzalez; Blas Couto; Jeffrey Antwi; Johnathan Sasitharan; Puja Bhakta; Gabor G. Kovacs; Susan Fox et al. The Impact of Neuropsychiatric Symptoms in Perceived Quality of Life in Patients With Progressive Supranuclear Palsy. European Journal of Neurology. 2025-06 DOI: 10.1111/ene.70248
Blas Couto; Maria Carmela Tartaglia; Gabor G. Kovacs; Anthony E. Lang. Differences in progressive supranuclear palsy in patients of Asian ancestry? Parkinsonism & Related Disorders. 2025-01 DOI: 10.1016/j.parkreldis.2024.107179
Garcia-Cordero I, Vargas-Gonzalez JC, Hadian M, et al. Language impairment is associated with faster progression in progressive supranuclear palsy-Richardson syndrome. Alzheimer's Dement. 2025; 21:e70485. https://doi.org/10.1002/alz.70485
Couto B, Kurian M, Friedman J, Lang A. et al. Diseases with acute exacerbation of movement disorders. Mov Disord. https://doi.org/10.1002/mds.29905
Couto, Di Luca, Antwi, Lang et al. “Ethnic background and distribution of clinical phenotypes in patients with probable progressive supranuclear palsy”. Parkinsonism Relat Disord. 2024. ver artículo
Couto, Marras, Di Luca. “Alfha-synuclein seed amplification in Parkinson's disease”. Lancet Neurol. 2023 Nov;22(11):983-984. ver artículo
Couto, B. Expert Commentary on Clinical and imaging "red flags" for the diagnosis of Multiple System Atrophy lookalikes: When to think out of the neurodegenerative box. Park & Rel Dis,2023.
Couto B, Fox S, Kovacs G, Lang A. et al. Experience and development of a clinical research program for Progressive Supranuclear Palsy. 2022, Canadian Journal of Neurological Sciences.
Couto, B, Martinez-Valbuena, I, Lee, S, et al. Protracted course progressive supranuclear palsy. Eur J Neurol. 2022; 00: 1–12. doi:10.1111/ene.15346
Tanaka H, Lee S, Couto B., et al. Ageing-related tau astrogliopathy severely affecting the substantia nigra. Neuropath and app Neurbiol. 50(4)13000. Doi:10.1111/nan.13000. ver articulo
Garcia-Cordero I, Anastassiadis C., Couto B. et al. Evaluating the Effect of Alzheimer's Disease-Related Biomarker Change in Corticobasal Syndrome and Progressive Supranuclear Palsy. Annals of Neurology. 2024;96(1):99-109. doi:10.1002/ana.26930. Epub 2024 Apr 5. ver articulo
Anastassiadis C, Martinez-Balbuena I, Couto B., et al. CSF α-Synuclein Seed Amplification Assay in Patients With Atypical Parkinsonian Disorder. 2024 Neurology; 103(6) https://doi.org/10.1212/WNL.0000000000209818. ver articulo
Lee S, Martinez-Valbuena I, de Andrea CE, Villalba-Esparza M, Ilaalagan S, Couto B, Visanji NP, Lang AE, Kovacs GG. Cell-specific dysregulation of iron and oxygen homeostasis as a novel pathophysiology in PSP. Ann Neurol. 2022 Oct 30. doi: 10.1002/ana.26540. ver articulo
Martinez-Valbuena I, Lee S, Couto B, et al. 4R-Tau seeding activity unravels molecular subtypes in patients with Progressive Supranuclear Palsy. lbioRxiv 2023.09.28.559953; doi: https://doi.org/10.1101/2023.09.28.559953
AlWazan, B.A., Garcia-Cordero, I., Couto, B. et al. Investigating differences in young- and late-onset progressive supranuclear palsy. J Neurol 270, 6103–6112 (2023). https://doi.org/10.1007/s00415-023-11976-9
Agradecemos a la Alzheimer's Association y a Cure PSP por apoyar nuestras investigaciones:
https://www.alz.org/research/for_researchers/grants/funded-studies-details?FundedStudyID=3290
Consorcio Argentino de Investigación Traslacional en Taupatías Primarias (CAITauP)