MEMORY AND COGNITION LABORATORY
Directors: Dr. Pedro Bekinschtein. Dr. Noelia Weisstaub
Members: Marcelo Giachero (assistant researcher). Belen Zanoni (PhD). Agostina Sacson (PhD), Mariana Imperatori (PhD), Pablo Koss (PhD), Daniel Ochoa (PhD), Antonella Furchi (PhD), Pedro Benedetti (PhD), Dinka Piromalli-Girado (PhD), Miguel Angel Martorell (CPA EEG) ), Florencia Alifano (CPA EEG), David Jaime (CPA vivarium), Dr. Pedro Cófreces (CPA).
Research lines
We study memory and cognition from a multilevel perspective. We are interested in the molecular mechanisms, circuits and different levels of processing of memory and other cognitive functions in the brain. At present we are focused on identifying and investigating the mechanisms of consolidation, evocation and active forgetting of memory and the brain mechanisms involved in social interaction.
Main publications
Retrieval of contextual memory can be predicted by CA3 remapping and is differentially influenced by NMDAR activity in rat hippocampus subregions. Magdalena Miranda, Azul Silva, Juan Facundo Morici, Marcos Antonio Coletti, Mariano Belluscio, Pedro Bekinschtein. Plos Biology, https://doi.org/10.1371/journal.pbio.3002706, Jul 1, 2024. see article
Acute and chronic physical activity improves spatial memory in an immersive virtual reality task.
Ramirez Butavand D, Rodriguez MF, Cifuentes MV, Miranda M, Bauza CG, Ballarini F, Bekinschtein P. iScience. 2023 Feb 10;26(3):106176. doi: 10.1016/j.isci.2023.106176. eCollection 2023 Mar 17. see article
Endocytosis is required for consolidation of pattern-separated memories in the perirhinal cortex.
Piromalli Girado D, Miranda M, Giachero M, Weisstaub N, Bekinschtein P. Front Syst Neurosci. 2023 Feb 23;17:1043664. doi: 10.3389/fnsys.2023.1043664. eCollection 2023. see article
Serotonin type 2a receptor in the prefrontal cortex controls perirhinal cortex excitability during object recognition memory recall. Juan Facundo Morici, Guido Cicuttin, Azul Silva, Francisco Tomás Gallo, Magdalena Miranda, Camila Zold, Pedro Bekinschtein, Noelia Victoria Weisstaub. Neuroscience, 2022 Aug 10:497:196-205. doi: 10.1016/j.neuroscience.2022.05.015. see article
Dopamine modulates adaptive forgetting in medial prefrontal cortex. Francisco T. Gallo, María Belén Zanoni Saad, Azul Silva, Juan Facundo Morici, Magdalena Miranda, Micheal Anderson, Noelia V. Weisstaub, Pedro Bekinschtein. The Journal of Neuroscience, 2022 Jul 18;JN-RM-0740-21.doi: 10.1523/JNEUROSCI.0740-21.2022. see article
A virtual reality platform for memory evaluation: Assessing effects of spatial strategies
María Florencia Rodríguez, Daniela Ramirez Butavand, María Virginia Cifuentes, Pedro Bekinschtein, Fabricio Ballarini, Cristian García Bauza. Behav Res Methods. 2021 Dec 16. doi: https://doi.org/10.3758/s13428-021-01758-4. see article
The spontaneous location recognition task for assessing spatial pattern separation and memory across a delay in rats and mice. Amy C. Reichelt, Cecilia P. Kramar, Olivia R. Ghosh-Swaby, Paul A. S. Sheppard,Brianne A. Kent, Pedro Bekinschtein, Lisa M. Saksida and Timothy J. Bussey. Nature Protocols, (2021). https://doi.org/10.1038/s41596-021-00627-w.
Molecular mechanisms within the Dentate Gyrus and the Perirhinal Cortex interact during discrimination of similar non spatial memories. Magdalena Miranda, Juan Facundo Morici, Francisco Gallo, Dinka Piromalli Girado, Noelia V. Weisstaub y Pedro Bekinschtein. Hippocampus Oct 2020. see article
Dentate gyrus somatostatin cells are required for contextual discrimination during episodic memory encoding. Cristian Morales, Juan Facundo Morici, Nelson Espinosa, Agostina Sacson, Ariel Lara-Vasquez, M.A García-Pérez, Pedro Bekinschtein, Noelia V. Weisstaub and Pablo Fuentealba. Cerebral Cortex, Oct 2020 doi: 10.1093/cercor/bhaa273. see article
Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain. Magdalena Miranda, Juan Facundo Morici, María Belén Zanoni and Pedro Bekinschtein. Frontiers in Cellular Neuroscience, 07 August 2019 https://doi.org/10.3389/fncel.2019.00363. see article
A Retrieval-Specific Mechanism of Adaptive Forgetting in the Mammalian Brain. Pedro Bekinschtein, Noelia Weisstaub, Francisco Gallo, Maria Renner and Michael C. Anderson. Nature Communications. 2018 Nov 7;9(1):4660. see article
BDNF and NMDA receptors interact in the dentate gyrus and the perirhinal cortex during consolidation of spatial and non-spatial overlapping memories. Magdalena Miranda, Brianne A. Kent, Lisa M. Saksida, Timothy J. Bussey and Pedro Bekinschtein. Neurobiol Learn Mem. 2018 Aug 30;155:337-343. see article
5-HT 2a receptor in mPFC controls context-guided retrieval and reconsolidation of object memory in Perirhinal Cortex. Juan Facundo Morici, Magdalena Miranda, Francisco Tomas Gallo, Belen Zanoni Saad, Pedro Bekinschtein and Noelia V Weisstaub. eLife. 2018 May 2;7. pii: e33746. see article
Molecular mechanisms in perirhinal cortex selectively necessary for pattern separation, but independent of memory persistence. Magdalena Miranda, Brianne A. Kent, Lisa M. Saksida, Timothy J. Bussey and Pedro Bekinschtein. eNeuro 4 (5), ENEURO. 0293-17.2017. see article
Serotonin 2a Receptor and serotonin 1a receptor interact within the medial prefrontal cortex during recognition memory in mice. Juan F. Morici, Lucia Ciccia, Gaël Malleret, Jay Gingrich, Pedro Bekinschtein and Noelia Weisstaub. Frontiers in Pharmacology. 2015. doi: 10.3389/fphar.2015.00298. see article
LABORATORY OF DYNAMICS MIND, BODY AND BRAIN (DINAMYC)
Directors: Dr. Adrián Yoris (director), Dr. Marcelo Cetkovich (co-director)
Members: Researchers: Dr. Sofía Abrevaya, Dr. Laura De la Fuente, Dr. Fernando Torrente, Dr. Pablo López. Miguel Angel Martorell (CPA EEG), Florencia Alifano (CPA EEG). Collaborators: Lic. Daniela Rios, Lic. Delfina Aylan, Lic. Martin Viberti. Scholarship holders and interns. Lorena Canziani, Kim Szlafsztein. International collaborators: Sarah Garfinkel, Eiko Fried, Camilla Nord, Hugo Critchley, Tim Dalgleish
Research lines
We study human behavior, both normal and pathological, through dimensional and multilevel models. We explore the dynamics between mind, body and brain through the dimensions of interoception, emotional regulation and cognitive control, with the aim of developing psychopathological profiles of anxiety and depression. We are interested in understanding how external temporal dynamics, using structured natural stimuli such as narratives and music, are related to brain dynamics, evaluating their diagnostic and therapeutic potential. To do this, we apply computational modeling strategies together with classical approaches. Additionally, we use predictive models to identify the triggers of these disorders using ecological information analysis (EMA). We also investigated brain dynamics related to eating behavior and body image under the interoception paradigm.
Main publications
Yoris, A. E., Cira, L. F., Luque-Casado, A., Salvotti, C., Tajadura-Jiménez, A., Avancini, C., ... & Perakakis, P. (2024). Delving into the relationship between regular physical exercise and cardiac interoception in two cross-sectional studies. Neuropsychologia, 198, 108867. see article
Yoris, A., Deleglise, A., del Cerro, J. P., Pascariello, G., Donelly-Kehoe, P., Cetkovich, M., & Torrente, F. (2023). Looking for a needle in a haystack: A machine-learning study of cognitive-behavioral constructs and symptoms for diagnosing single and comorbid anxiety disorders. see article
Speranza, Trinidad Belen, Sofia Abrevaya, and Veronica Claudia Ramenzoni. "Cross-generational EDects of Social Media on Body Image Perception." (2024). see article
Aragón-Daud, Oberti De Luca A, Schurmann Vignaga S, Prado P, Figueras R, Lizaso L, González-Gadea, Manes, Cetkovich, Pallavicini, Torralva, de la Fuente LA. Attentional ERPs in consumers of smoked and insufflated cocaine associated with neuropsychological performance. Drug and Alcohol Dependence, 2024. DOI: 10.1016/j.drugalcdep.2024.111288. see article
de la Fuente, Zamberland, Boccacio, Tagliazucchi. Temporal irreversibility of neural dynamics is a signature of consciousness. Cereb Cortex, 2022. DOI: 10.1093/cercor/bhac177. see article
Naumann*, Byrne*, Harrewijn*, de la Fuente*, Nugiel, Rosen*, van Atteveldt*, Matusz*. Assessing the Degree of Ecological Validity of Your Study: Introducing the Multidimensional Assessment of Research in Context (MARC) Tool. Mind Brain Educ, 2021. DOI: 10.1111/mbe.12318. see article
de la Fuente, Schurmann-Vignagra, Prado, Figueras, Lizaso, Manes, Cetkovich, Tagliazucchi, Torralva. Early onset consumption of coca paste associated with executive-attention vulnerability markers linked to caudate-frontal structural and functional abnormalities. Drug and Alcohol Dependence, 2021. DOI: 10.1016/j.drugalcdep.2021.108926. see article
de la Fuente, Zamberlan, Carrillo, Tagliazucchi, Pallavicini. Relationship among subjective responses, flavor, and chemical composition across more than 800 commercial cannabis varieties. Journal of Cannabis Research, 2020. DOI: 10.1186/s42238-020-00028-y. see article
de la Fuente, Sedeño, Schurmann Vignaga, Ellmann, Sonzogni, Belluscio, García-Cordero, Castagnaro, Boano, Cetkovich, Torralva, Cánepa, Tagliazucchi, Garcia, Ibañez. Multimodal neurocognitive markers of interoceptive tuning in smoked cocaine. Neuropsychopharmacology, 2019. DOI: 10.1038/s41386-019-0370-3. see article
Muller, Cavanna, de la Fuente, Bruno, D’Amelio, Pallavicini, Tagliazucchi. Acute effects of psilocybin on the dynamics of gaze fixations during visual aesthetic perception. BioRxiv, 2023. DOI: 10.1101/2023.10.27.564413. see article
McKeon, Calabro, de la Fuente, Foran, Parr, Luna. Age-related differences in transient gamma band activity during working memory maintenance through adolescence. NeuroImage, 2023. DOI: 10.1016/j.neuroimage.2023.120112. Role: see article
Deco, Sanz Perl, de la Fuente, Sitt, Yeo, Tagliazucchi, Kringelbach. The arrow of time of brain signals in cognition: Potential intriguing role of parts of the default mode network. Network Neuroscience, 2022. DOI: 10.1162/netn_a_00300. see article
Cavanna, Mueller, de la Fuente, Zamberlan, Palmucci, Janeckova, Kuchar, Pallavicini, Tagliazucchi. Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study. Translational Psychiatry, 2022. DOI: 10.1038/s41398-022-02039-0. Role: Collaborated in the execution of experiments and contributed to the analysis and interpretation of results.
Sanz, Cavanna, Muller, de la Fuente, et al. Natural language signatures of psilocybin microdosing. Psychopharmacology (Berl), 2022. DOI: 10.1007/s00213-022-06170-0. see article
NPS AND LANGUAGE RESEARCH LABORATORY
Directors: Dr. María Roca. Dr. Teresa Torralva. Dr. Macarena Martínez Cuitiño. Dr. Clara Pinasco.
Members: Lic. Dolores Zamora (doctoral fellow), Lic. María Victoria Sánchez (doctoral fellow), Lic. Nicolás Romero (teacher), Josefina Castillo (teacher), Jorge Graneri (external collaborator), Lic. Marina Dolmatzian (doctoral student), Lic. Lujpan Naury (teacher), Lic. Juan Carrillo, Lic. Sofía Ruiz Barbarino, Lic. Karen Fernandez, Lic. Florencia basso, Lic. Candela Arazi.
Research lines
We study the cognitive failures that occur in various neurological and psychiatric disorders with the aim of not only contributing to their evaluation and treatment, but also to the understanding of normal brain functioning. In this way we study the neuropsychological profiles of patients with neurological and psychiatric diseases, such as Parkinson's disease, Frontotemporal Dementia, Schizophrenia or Bipolar Disease to then collaborate in the description of the neural bases of diverse cognitive functions such as Memory or Social Cognition. We also seek to gain an in-depth understanding of normal and pathological language processing, both at a behavioral and cerebral level, during childhood and adult life. This knowledge will allow the development of appropriate tools for the evaluation and design of theoretically based treatments in Spanish.
Main publications
Aragón-Daud, A., De Luca, S. M. O., Vignaga, S. S., Prado, P., Figueras, R., Lizaso, L., & de la Fuente, L. A. (2024). Attentional ERPs in consumers of smoked and insufflated cocaine associated with neuropsychological performance. Drug and Alcohol Dependence, 259, 111288. see article
Bruno, D., Sánchez Rueda, D., Lopez, E., Pinasco, C., Torralva, T., Alfredo, T., Sierra Sanjurjo, N., & Roca, M. (2024). Validity and norms for young adults for the Aggie Figures Learning Test. Applied neuropsychology. Adult, 1–7. Advance online publication. https://doi.org/10.1080/23279095.2024.2354856
Zamora DJ, Camilotto NR, Romero NN, Shalom DE, y Martínez-Cuitiño M. (2024). Normas categoriales para adolescentes hablantes del español rioplatense. Revista de Investigación en Logopedia 14(1), e86859. https://dx.doi.org/10.5209/rlog.86859. see article
Zamora D, Shalóm DE, Romero N, Barreyro JP & Martínez-Cuitiño, M. (2024). Datos normativos de niños argentinos de escuela primaria. Interdisciplinaria 41 (1), 5-6. https://doi.org/10.16888/interd.2024.41.1.5
Aragón-Daud, A., Oberti de Luca, S. M., Schurmann Vignaga, S., Prado, P., Figueras, R., Lizaso, L., & de la Fuente, L. A. (2023). Differential modulation of attentional ERPs in smoked and insufflated cocaine-dependent associated with neuropsychological performance. medRxiv, 2023-07. see article
Martínez Cuitiño M, Zamora D, Romero N & Barreyro JP (2023). Emojis en tareas de categorización: Una nueva forma de evaluar el conocimiento conceptual. Revista de Psicología, 19 (38), 25-40. ISSN 1669-2438 ISSN-electrónico 2469-2050 https://doi.org/10.46553/RPSI.19.38.2023.p25-40. see article
Pinasco, C. M., Herrera, E., Bruno, D., Torralva, T., & Roca, M. (2023). Valores normativos para el Test del Hotel en adultos jóvenes de Buenos Aires. Neurología Argentina, 15(1), 8-14. see article
Pinasco C, Oviedo M, Goldfeder M, Bruno D, Lischinsky A, Torralva T, Roca M. (2023). Sensitivity and specificity of the INECO frontal screening (IFS) in the detection of patients with traumatic brain injury presenting executive deficits. Appl Neuropsychol Adult. May-Jun;30(3):289-296. doi: 10.1080/23279095.2021.1937170. see article
Vivas L, Martínez Cuitiño M, Manoiloff L, Romanelli S & Garrard P (2023). Traducción y adaptación lingüística y cultural del Minilinguistic State Examination al español de Argentina. Revista Argentina de Ciencias del Comportamiento (RACC), 15(3), 82-98.see article
Zamora D, Barreyro JP, Sánchez MV & Martínez-Cuitiño M. (2023). Comprensión de oraciones con cláusulas relativas en niños hablantes del español rioplatense. Lengua y sociedad. Revista de Lingüística Teórica y Aplicada, 22(2), 187-203. ISSN 1729-9721 e-ISSN 2413-2659. https://doi.org/10.15381/lengsoc.v22i2.23934. see article
Graneri J, Dansilio S, Martínez Cuitiño M, Grasso L, Cantore S & Brasca L (2022). Dissociation between function and manipulation in semantic representations of motor impaired subjects: a new test. Cognitive Neuropsychology 39(3-4); 208-226. https://doi.org/10.1080/02643294.2022.2114825
Henríquez, F., Cabello, V., Baez, S., de Souza, L. C., Lillo, P., Martínez-Pernía, D., Olavarría, L., Torralva, T., & Slachevsky, A. (2022). Multidimensional Clinical Assessment in Frontotemporal Dementia and Its Spectrum in Latin America and the Caribbean: A Narrative Review and a Glance at Future Challenges. Frontiers in neurology, 12, 768591. https://doi.org/10.3389/fneur.2021.768591. see article
López, P. L., Testa, T., Teresa, T., Roca, M., & Manes, F. (2022). Differential Profile of High-Performance Adults with Attention Deficit Hyperactivity Disorder. J Clinical Research and Reports, 10(5), 2690-1919. see article
Smith, V., Pinasco, C., Achterberg, J., Mitchell, D. J., Das, T., Roca, M., & Duncan, J. (2022). Fluid intelligence and naturalistic task impairments after focal brain lesions. Cortex; a journal devoted to the study of the nervous system and behavior, 146, 106–115. https://doi.org/10.1016/j.cortex.2021.09.020. see article
de la Fuente, A., Vignaga, S. S., Prado, P., Figueras, R., Lizaso, L., Manes, F., Cetkovich, M., Tagliazucchi, E., & Torralva, T. (2021). Early onset consumption of coca paste associated with executive-attention vulnerability markers linked to caudate-frontal structural and functional abnormalities. Drug and alcohol dependence, 227, 108926. https://doi.org/10.1016/j.drugalcdep.2021.108926. see article
Gonzalez-Gomez, R., Rodríguez-Villagra, O. A., Schulte, M., Torralva, T., Ibáñez, A., Huepe, D., & Fittipaldi, S. (2021). Neurocognitive factorial structure of executive functions: Evidence from neurotypicals and frontotemporal dementia. Cortex; a journal devoted to the study of the nervous system and behavior, 145, 79–96. https://doi.org/10.1016/j.cortex.2021.08.015. see article
Llibre-Guerra, J. J., Behrens, M. I., Hosogi, M. L., Montero, L., Torralva, T., Custodio, N., Longoria-Ibarrola, E. M., Giraldo-Chica, M., Aguillón, D., Hardi, A., Maestre, G. E., Contreras, V., Doldan, C., Duque-Peñailillo, L., Hesse, H., Roman, N., Santana-Trinidad, D. A., Schenk, C., Ocampo-Barba, N., López-Contreras, R., … Nitrini, R. (2021). Frontotemporal Dementias in Latin America: History, Epidemiology, Genetics, and Clinical Research. Frontiers in neurology, 12, 710332. https://doi.org/10.3389/fneur.2021.710332. see article
Bachli, M. B., Sedeño, L., Ochab, J. K., Piguet, O., Kumfor, F., Reyes, P., Torralva, T., Roca, M., Cardona, J. F., Campo, C. G., Herrera, E., Slachevsky, A., Matallana, D., Manes, F., García, A. M., Ibáñez, A., & Chialvo, D. R. (2020). Evaluating the reliability of neurocognitive biomarkers of neurodegenerative diseases across countries: A machine learning approach. NeuroImage, 208, 116456. https://doi.org/10.1016/j.neuroimage.2019.116456. see article
Bruno, D., Slachevsky, A., Fiorentino, N., Rueda, D. S., Bruno, G., Tagle, A. R., Olavarria, L., Flores, P., Lillo, P., Roca, M., & Torralva, T. (2020). Argentinian/Chilean validation of the Spanish-language version of Addenbrooke's Cognitive Examination III for diagnosing dementia. Validación argentino-chilena de la versión en español del test Addenbrooke's Cognitive Examination III para el diagnóstico de demencia. Neurologia, 35(2), 82–88. https://doi.org/10.1016/j.nrl.2017.06.004. see article
de la Fuente, A., Vignaga, S. S., Prado, P., Figueras, R., Lizaso, L., Manes, F., Cetkovich, M., Tagliazucchia, E. & Torralva, T. (2020). Structural and functional signatures of executive deficits after early use of cocaine depend upon route of administration. medRxiv, 2020-06. see article
Goitia, B., Bruno, D., Abrevaya, S., Sedeño, L., Ibáñez, A., Manes, F., Sigman, M., Sinay, V., Torralva, T., Duncan, J., & Roca, M. (2020). The relationship between executive functions and fluid intelligence in multiple sclerosis. PloS one, 15(4), e0231868. https://doi.org/10.1371/journal.pone.0231868. see article
Soriano FG. & Martínez-Cuitiño M. (2020). Pasado, presente y futuro de las Afasias Progresivas Primarias: Una actualización bibliográfica. Revista de Psicología. Universidad Católica Argentina (UCA). Vol16 (31), 7-28. ISSN 1669-2438. see article
Calvo S, Abrevaya S, Martínez-Cuitiño M, Steeb B; Zamora D, Sedeño L, Ibañez A, García A. (2019). Rethinking the neural basis of prosody and non-literal language: Spared pragmatics and cognitive compensation in a bilingual with extensive right hemisphere damage. Frontiers in Psychology 10, Art 570. https://doi.org/10.3389/fpsyg.2019.00570. see article
de la Fuente, A., Sedeño, L., Vignaga, S. S., Ellmann, C., Sonzogni, S., Belluscio, L., García-Cordero, I., Castagnaro, E., Boano, M., Cetkovich, M., Torralva, T., Cánepa, E. T., Tagliazucchi, E., Garcia, A. M., & Ibañez, A. (2019). Multimodal neurocognitive markers of interoceptive tuning in smoked cocaine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 44(8), 1425–1434. https://doi.org/10.1038/s41386-019-0370-3. see article
Martínez-Cuitiño M, Peccin A, Soriano F, Barreyro JP. (2019). Efectos categoriales en tareas de denominación y categorización de dibujos con y sin color. Cuadernos de Neuropsicología 13(2). https://doi.org/10.7714/CNPS/13.2.203. see article
Martínez-Cuitiño M, Soriano F, Jaichenco V, Steeb B, Barreyro JP. (2019). Predictors of naming and picture categorization in Spanish. East European Journal of Psycholinguistic 6(1), 6–18; doi: https://doi.org/10.5281/zenodo.3365959. see article
Martínez-Cuitiño M, Vivas, L. (2019). Category or Diagnosticity Effect? The Influence of Color in Picture Naming Tasks. Psychology & Neuroscience 12(3), 328-341. https://doi.org/10.1037/pne0000172.
Sierra Sanjurjo, N., Saraniti, A. B., Gleichgerrcht, E., Roca, M., Manes, F., & Torralva, T. (2019). The IFS (INECO Frontal Screening) and level of education: Normative data. Applied neuropsychology. Adult, 26(4), 331–339. https://doi.org/10.1080/23279095.2018.1427096. see article
Soriano, F. G., Zamora, D., Ferrari, J., & Martínez-Cuitiño, M. (2019). Efecto de concretud inverso en Afasia Progresiva variante semántica: estudio longitudinal de un paciente. Revista Iberoamericana de Psicología, 12 (2), 51-60. see article
LABORATORY OF PROGRESSIVE NEUROMOTOR AND NEUROCEANHAVIORAL DISORDERS
Director: Dr. Blas Couto
Members: Lic. Federico Castaño (doctoral fellow), Dr. María José Angel (clinical fellow), Miguel Angel Martorell (CPA EEG), Florencia Alifano (CPA EEG). Tomás Falzone (UBA-IBioBA collaborator), Elena Avale (external INGEBI collaborator). Nicolas Vallenas (NYU medicine student, USA), Laura Zaifrani (teacher), Mateo Tomkowicz (medical student, Univ. Austral).
Research lines
We seek to understand through our studies the genetics of parkinsonisms, and the environmental exposures and lifestyle factors that impact the symptoms of PSP and parkinsonisms. We will also investigate possible genetic-environmental interactions. On the other hand, we developed batteries of cognitive studies to monitor the neurobehavioral changes of patients with PSP. In another line, we delve into the knowledge of neurobiological markers (with EEG and evoked potentials) of impulsivity. We study the epidemiology, clinical phenotypes, progression and molecular neurobiology of patients with Parkinsonism and dementia: Progressive supranuclear palsy, particularly.
Main publications
Couto B, Kurian M, Friedman J, Lang A. et al. Diseases with acute exacerbation of movement disorders. Mov Disord. https://doi.org/10.1002/mds.29905
Couto, Di Luca, Antwi, Lang et a. “Ethnic background and distribution of clinical phenotypes in patients with probable progressive supranuclear palsy”. Parkinsonism Relat Disord. 2024. see article
Couto, Marras, Di Luca. “Alfha-synuclein seed amplification in Parkinson's disease”. Lancet Neurol. 2023 Nov;22(11):983-984. see article
Couto, B. Expert Commentary on Clinical and imaging "red flags" for the diagnosis of Multiple System Atrophy lookalikes: When to think out of the neurodegenerative box. Park & Rel Dis,2023.
Couto B, Fox S, Kovacs G, Lang A. et al. Experience and development of a clinical research program for Progressive Supranuclear Palsy. 2022, Canadian Journal of Neurological Sciences.
Couto, B, Martinez-Valbuena, I, Lee, S, et al. Protracted course progressive supranuclear palsy. Eur J Neurol. 2022; 00: 1–12. doi:10.1111/ene.15346
Tanaka H, Lee S, Couto B., et al. Ageing-related tau astrogliopathy severely affecting the substantia nigra. Neuropath and app Neurbiol. 50(4)13000. Doi:10.1111/nan.13000. ver articulo
Garcia-Cordero I, Anastassiadis C., Couto B. et al. Evaluating the Effect of Alzheimer's Disease-Related Biomarker Change in Corticobasal Syndrome and Progressive Supranuclear Palsy. Annals of Neurology. 2024;96(1):99-109. doi:10.1002/ana.26930. Epub 2024 Apr 5. see article
Anastassiadis C, Martinez-Balbuena I, Couto B., et al. CSF α-Synuclein Seed Amplification Assay in Patients With Atypical Parkinsonian Disorder. 2024 Neurology; 103(6) https://doi.org/10.1212/WNL.0000000000209818. ver articulo
Lee S, Martinez-Valbuena I, de Andrea CE, Villalba-Esparza M, Ilaalagan S, Couto B, Visanji NP, Lang AE, Kovacs GG. Cell-specific dysregulation of iron and oxygen homeostasis as a novel pathophysiology in PSP. Ann Neurol. 2022 Oct 30. doi: 10.1002/ana.26540. see article
Martinez-Valbuena I, Lee S, Couto B, et al. 4R-Tau seeding activity unravels molecular subtypes in patients with Progressive Supranuclear Palsy. lbioRxiv 2023.09.28.559953; doi: https://doi.org/10.1101/2023.09.28.559953
AlWazan, B.A., Garcia-Cordero, I., Couto, B. et al. Investigating differences in young- and late-onset progressive supranuclear palsy. J Neurol 270, 6103–6112 (2023). https://doi.org/10.1007/s00415-023-11976-9