LABORATORIO DE MEMORIA Y COGNICION

Directores: Dr. Pedro Bekinschtein. Dra. Noelia Weisstaub

Integrantes: Marcelo Giachero (investigador asistente). Belen Zanoni (doctorado). Agostina Sacson (doctorado), Mariana Imperatori (doctorado), Pablo Koss (doctorado), Daniel Ochoa (doctorado), Antonella Furchi (doctorado), Pedro Benedetti (doctoral), Dinka Piromalli-Girado (doctoral), Miguel Angel Martorell (CPA EEG), Florencia Alifano (CPA EEG), David Jaime (CPA bioterio), Dr. Pedro Cófreces (CPA).

Líneas de investigación

Estudiamos la memoria y la cognición desde una perspectiva multinivel. Nos interesan los mecanismos moleculares, los circuitos y los diferentes niveles de procesamiento de la memoria y otras funciones cognitivas en el cerebro. En el presente estamos enfocados en identificar e investigar los mecanismos de consolidación, evocación y olvido activo de la memoria y los mecanismos cerebrales involucrados en la interacción social.

 

Principales publicaciones

Retrieval of contextual memory can be predicted by CA3 remapping and is differentially influenced by NMDAR activity in rat hippocampus subregions. Magdalena Miranda, Azul Silva, Juan Facundo Morici, Marcos Antonio Coletti, Mariano Belluscio, Pedro Bekinschtein. Plos Biology, https://doi.org/10.1371/journal.pbio.3002706, Jul 1, 2024.

Acute and chronic physical activity improves spatial memory in an immersive virtual reality task.
Ramirez Butavand D, Rodriguez MF, Cifuentes MV, Miranda M, Bauza CG, Ballarini F, Bekinschtein P. iScience. 2023 Feb 10;26(3):106176. doi: 10.1016/j.isci.2023.106176. eCollection 2023 Mar 17.

Endocytosis is required for consolidation of pattern-separated memories in the perirhinal cortex.
Piromalli Girado D, Miranda M, Giachero M, Weisstaub N, Bekinschtein P. Front Syst Neurosci. 2023 Feb 23;17:1043664. doi: 10.3389/fnsys.2023.1043664. eCollection 2023.

Serotonin type 2a receptor in the prefrontal cortex controls perirhinal cortex excitability during object recognition memory recall. Juan Facundo Morici, Guido Cicuttin, Azul Silva, Francisco Tomás Gallo, Magdalena Miranda, Camila Zold, Pedro Bekinschtein, Noelia Victoria Weisstaub. Neuroscience, 2022 Aug 10:497:196-205. doi: 10.1016/j.neuroscience.2022.05.015

Dopamine modulates adaptive forgetting in medial prefrontal cortex. Francisco T. Gallo, María Belén Zanoni Saad, Azul Silva, Juan Facundo Morici, Magdalena Miranda, Micheal Anderson, Noelia V. Weisstaub, Pedro Bekinschtein. The Journal of Neuroscience, 2022 Jul 18;JN-RM-0740-21.doi: 10.1523/JNEUROSCI.0740-21.2022..

A virtual reality platform for memory evaluation: Assessing effects of spatial strategies
María Florencia Rodríguez, Daniela Ramirez Butavand, María Virginia Cifuentes, Pedro Bekinschtein, Fabricio Ballarini, Cristian García Bauza. Behav Res Methods. 2021 Dec 16. doi: https://doi.org/10.3758/s13428-021-01758-4

The spontaneous location recognition task for assessing spatial pattern separation and memory across a delay in rats and mice. Amy C. Reichelt, Cecilia P. Kramar, Olivia R. Ghosh-Swaby, Paul A. S. Sheppard,Brianne A. Kent, Pedro Bekinschtein, Lisa M. Saksida and Timothy J. Bussey. Nature Protocols, (2021). https://doi.org/10.1038/s41596-021-00627-w

Molecular mechanisms within the Dentate Gyrus and the Perirhinal Cortex interact during discrimination of similar non spatial memories. Magdalena Miranda, Juan Facundo Morici, Francisco Gallo, Dinka Piromalli Girado, Noelia V. Weisstaub y Pedro Bekinschtein. Hippocampus Oct 2020

Dentate gyrus somatostatin cells are required for contextual discrimination during episodic memory encoding. Cristian Morales, Juan Facundo Morici, Nelson Espinosa, Agostina Sacson, Ariel Lara-Vasquez, M.A García-Pérez, Pedro Bekinschtein, Noelia V. Weisstaub and Pablo Fuentealba. Cerebral Cortex, Oct 2020 doi: 10.1093/cercor/bhaa273

Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain. Magdalena Miranda, Juan Facundo Morici, María Belén Zanoni and Pedro Bekinschtein. Frontiers in Cellular Neuroscience, 07 August 2019 https://doi.org/10.3389/fncel.2019.00363

A Retrieval-Specific Mechanism of Adaptive Forgetting in the Mammalian Brain. Pedro Bekinschtein, Noelia Weisstaub, Francisco Gallo, Maria Renner and Michael C. Anderson. Nature Communications. 2018 Nov 7;9(1):4660

BDNF and NMDA receptors interact in the dentate gyrus and the perirhinal cortex during consolidation of spatial and non-spatial overlapping memories. Magdalena Miranda, Brianne A. Kent, Lisa M. Saksida, Timothy J. Bussey and Pedro Bekinschtein. Neurobiol Learn Mem. 2018 Aug 30;155:337-343

5-HT 2a receptor in mPFC controls context-guided retrieval and reconsolidation of object memory in Perirhinal Cortex. Juan Facundo Morici, Magdalena Miranda, Francisco Tomas Gallo, Belen Zanoni Saad, Pedro Bekinschtein and Noelia V Weisstaub. eLife. 2018 May 2;7. pii: e33746.

Molecular mechanisms in perirhinal cortex selectively necessary for pattern separation, but independent of memory persistence. Magdalena Miranda, Brianne A. Kent, Lisa M. Saksida, Timothy J. Bussey and Pedro Bekinschtein. eNeuro 4 (5), ENEURO. 0293-17.2017

Serotonin 2a Receptor and serotonin 1a receptor interact within the medial prefrontal cortex during recognition memory in mice. Juan F. Morici, Lucia Ciccia, Gaël Malleret, Jay Gingrich, Pedro Bekinschtein and Noelia Weisstaub. Frontiers in Pharmacology. 2015. doi: 10.3389/fphar.2015.00298